3 7 9 Furthermore, it requires admission to hospital. To date, only a few studies have evaluated the efficacy of oral penicillin12 or macrolides14 versus standard penicillin to treat erysipelas or acute cellulitis. Pristinamycin, a natural streptogramin commonly used in some European countries https://www.jewelryfyku.top/, particularly France, is especially active against Streptococcus pyogenes (minimum inhibitory concentration 0.12 mg/l).15 In a preliminary open study, pristinamycin cured 86% of adult patients admitted to hospital with erysipelas.16We undertook a large scale investigation to compare the efficacies of oral pristinamycin and intravenous then oral penicillin in treating hospital patients with erysipelas.Study designThe study was a randomised open label, parallel group clinical trial designed to assess the non inferiority of oral pristinamycin versus a standard intravenous then oral penicillin regimen.

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